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Hormone Replacement Therapy Weighing the Benefits and Risks by Mariella Krause
No one looks forward to menopause. Kind of like the flip side of puberty, menopause is when a woman's body starts decreasing its production of female hormones. Along with that come a slew of unpleasant symptoms, such as hot flashes, anxiety, depression and sleeplessness. For many years, doctors recommended hormone replacement therapy to deal with these symptoms and restore a little normalcy for the woman going through menopause. They also prescribed it for women at high risk for Alzheimer's, osteoporosis and other diseases, and many women considered it the answer to their prayers. However, recent studies have shown that the risks may outweigh the benefits, and the topic of HRT has become both confusing and controversial. If you're thinking that hormone replacement therapy might be right for you, you'll obviously have to talk to your doctor first. But before you get that far, here are some things you might want to know to help you decide.
What It Is There are two types of hormone therapy: HRT and ERT. HRT (hormone replacement therapy) provides a combination of both estrogen and progestin, while ERT (estrogen replacement therapy) replaces only the estrogen in a woman's body. The progestin in HRT helps decrease the risk of endometrial cancer, which is why ERT is typically used only by women who have had a hysterectomy. Some women also take androgens in addition to the estrogen. Androgens, mostly testosterone, are prescribed for women who are undergoing surgical menopause or who are experiencing loss of libido and other symptoms of testosterone deficiency during natural menopause.
Benefits of Hormone Therapy Many patients at risk for Alzheimer's or colon cancer have embraced HRT, as it decreases the risk of both of those diseases. In fact, one study showed that women were two and a half times less likely to develop Alzheimer's after taking HRT for more than ten years. Hormone therapy also can slow or stop the loss of bone mass associated with osteoporosis when taken for longer periods of time, which also could be good news for some women. For a while, many experts believed that HRT also reduced the risk of heart disease, but new studies show that it actually might slightly increase the risk (if you see that listed as a possible benefit, you might be dealing with outdated information).
Side Effects Many women have also reported experiencing dizziness or drowsiness, headaches, diarrhea, and vaginal dryness. (Some women believe that HRT also causes weight gain; however, that one is simply the fault of a slower metabolism.) Many of these symptoms are specifically related to the progestin, and can be reduced by adjusting the dose or schedule, using a different type of progestin, or switching to estrogen-only ERT if there is an acceptably low risk of cancer of the uterus.
Long-Term Risks A major study was underway investigating the long-term effects of hormone therapy, but was suddenly halted when the researchers discovered some startling news: an increase in the risk of breast cancer, stroke, heart attacks and blood clots among study participants. HRT has also been linked to increased risk of endometrial cancer, ovarian cancer and gallstones. Researchers still need to determine exactly what amount of risk we're dealing with, but for women considering hormone therapy, the seriousness of these diseases have certainly given them pause -- especially those for whom menopausal symptoms are annoying but not unbearable.
HRT and Breast Cancer Taking combination HRT can also affect your breast density, which can make mammograms more difficult to read. And naturally denser breasts are more prone to breast cancer -- although it is not known whether breasts that are denser as a result of HRT carry the same risks. While there is no definite proof that HRT causes breast cancer, the risk is certainly something to consider, especially if you have a family history or other factors that put you at a higher risk.
Who Should Not Take HRT
Alternatives to HRT To begin with, antidepressants like Prozac and Zoloft can be very effective in treating depression and mood swings, and they may also help with hot flashes. Clonidine, a drug typically used for high blood pressure, can also alleviate hot flashes. There are several options for treating osteoporosis, and certain cholesterol-lowering drugs are proven to be effective for reducing the risk of heart disease. Of course, there are natural remedies, as well. Researchers have studied the effectiveness of vitamin E therapy, acupuncture, wild yam and progesterone cream, but results have been unimpressive. However, foods that contain phytoestrogens, such as soy products and flaxseed, might help relieve hot flashes and night sweats, and vitamin E is said to relieve hot flashes, as well. Last but not least, there's the one tried-and-true method that no one disagrees with: plain old common sense and basically just taking good care of your body. Here are some tactics everyone should try:
Herbal Remedies
What to Think About
Of course, you'll need to talk to your doctor before you can make a
final decision. So if you think you might want to try HRT, schedule an
appointment to discuss all the risks and benefits and how they fit in
with your personal health.
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